Nk’uko ubushakashatsi bushya bwakozwe n’abashakashatsi bo muri UT Health San Antonio hamwe n’ibigo bibafatanyabikorwa, abantu bageze mu za bukuru bafite ibimenyetso byo kwiheba bitwaza poroteyine yitwa APOE.Guhinduka kwa epsilon 4 Gicurasi birashoboka cyane kubyara tau kwiyubaka mubice byubwonko bigenzura imyumvire no kwibuka.
Ibyavuye mu bushakashatsi byasohotse mu kinyamakuru cyo muri Kamena 2021 cyasohotse mu kinyamakuru cy’indwara ya Alzheimer.Ubushakashatsi bwari bushingiye ku gusuzuma no kwiheba hamwe na positron yoherejwe na tomografiya (PET) yerekana abitabiriye 201 bitabiriye Kwiga Umutima wa Framingham.Impuzandengo yimyaka yabitabiriye yari 53.
Birashoboka kubona indwara mbere yimyaka yo kwisuzumisha
Ubusanzwe PET ikorerwa mu bantu bakuze, bityo rero FAMingham YIGA kuri PET mu myaka yo hagati irihariye, nk'uko byatangajwe na Mitzi M. Gonzales, umwanditsi mukuru w’ubushakashatsi akaba n’inzobere mu bijyanye n’imitsi mu kigo cya Glenn Biggs Institute for Alzheimer and Disease Neurodegenerative, bikaba biri mu bigize Ikigo nderabuzima cya kaminuza ya Texas kuri SAN Antonio.
Dr. Gonzales yagize ati: "Ibi biduha amahirwe ashimishije yo kwiga abantu bageze mu za bukuru no kumva ibintu bishobora kuba bifitanye isano no kwegeranya poroteyine mu bantu basanzwe bazi ubwenge"."Niba aba bantu bakomeje kugira ikibazo cyo guta umutwe, ubu bushakashatsi buzavumbura ibyo bishoboka mbere yo kwisuzumisha."
Ntaho bihuriye na beta-amyloide
Beta-amyloide (Aβ) na Tau ni poroteyine zegeranya mu bwonko bw'abantu barwaye Alzheimer kandi ubusanzwe ziyongera buhoro buhoro n'imyaka.Ubushakashatsi bwerekanye ko nta sano riri hagati yibimenyetso byo kwiheba no kwiheba na beta-amyloide.Byahujwe gusa na Tau, kandi gusa nabatwara APOE ε4 mutation.Hafi ya kimwe cya kane cy’abarwayi 201 (47) batwaye gene ya ε4 kuko bafite byibura ε4 allele.
Gutwara kopi imwe ya gene ya APOEε4 byongera ibyago byo kurwara alzheimer inshuro ebyiri cyangwa eshatu, ariko abantu bamwe bitwaza gene barashobora kubaho mumyaka 80 cyangwa 90 batigeze barwara iyo ndwara.Dr. Gonzales yagize ati: "Ni ngombwa kwibuka ko kuba umuntu amenyekana ko yitwaje APOE ε4 bidasobanura ko mu gihe kiri imbere azarwara umutwe."Bisobanura gusa ko imigabane iri hejuru. "
Ibimenyetso byo kwiheba (kwiheba niba ibimenyetso bikabije bihagije kugirango uhuze iyi mbago yo kwisuzumisha) byapimwe mugihe cyo gufata amashusho ya PET hamwe nimyaka umunani mbere yo gukoresha Epidemiologue Research Centre Depression Scale.Ibimenyetso byo kwiheba hamwe nisano iri hagati yo kwiheba nibisubizo bya PET kumwanya wibihe bibiri byapimwe, bihindurwa kumyaka nuburinganire.
Ibigo byamarangamutima no kumenya
Ubushakashatsi bwerekanye isano iri hagati yibimenyetso byo kwiheba no kwiyongera kwa tau mu bice bibiri byubwonko, cortex entorhinal na amygdala.Dr. Gonzales ati: "Aya mashyirahamwe ntabwo asobanura ko kwirundanya kwa tau bitera ibimenyetso byo kwiheba cyangwa ubundi.""Twabonye gusa ibi bintu byombi mu batwara ε4."
Yagaragaje ko cortex ya entorhinal ari ingenzi mu guhuriza hamwe kwibuka kandi ikunda kuba ahantu haterwa poroteyine hakiri kare.Hagati aho, amygdala yatekereje kuba amarangamutima yubwonko.
Dr. Gonzales yagize ati: "Ubushakashatsi bumaze igihe kirekire burakenewe kugira ngo turusheho gusobanukirwa n'ibiri gukorwa, ariko birashimishije gutekereza ku ngaruka zishingiye ku mavuriro y'ibyo twabonye mu bijyanye no kumenya no kumenya amarangamutima".
Igihe cyo kohereza: 26-08-21